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1

Preparation of 3-amino-1,4-benzodiazepin-2-ones via direct azidation with trisyl azide

John W. Butcher, Nigel J. Liverton, Harold G. Selnick, Jason M. Elliot, Garry R. Smith, Andrew J. Tebben, David A. Pribush, John S. Wai, David A. Claremon

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 177 KB

english, 1996

2

Identification and Characterization of 4-Methylbenzyl 4-[(Pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an Orally Bioavailable, Brain Penetrant NR2B Selective N-Methyl-d-Aspartate Receptor Antagonist

Libby, Brian E., Liverton, Nigel J., Bednar, Rodney A., Bednar, Bohumil, Butcher, John W., Claiborne, Christopher F., Claremon, David A., Cunningham, Michael, DiLella, Anthony G., Gaul, Stanley L.

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 194 KB

english, 2007

3

Non-peptide fibrinogen receptor antagonists. 21. The synthesis of [3H]L-738,167

Terence G. Hamill, Ben C. Askew, George D. Hartman, David A. Claremon, Charles J. McIntyre, H. Donald Burns

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

1998

File:

PDF, 273 KB

1998

4

ChemInform Abstract: Nonpeptide Glycoprotein IIb/IIIa Inhibitors. Part 13. Design and Synthesis of an Orally Active Pyrazolopiperazinone Nonpeptide Fibrinogen Receptor Antagonist.

B. C. ASKEW, C. J. MCINTYRE, C. A. HUNT, D. A. CLAREMON, J. J. BALDWIN, P. S. ANDERSON, R. J. GOULD, R. J. LYNCH, C. C.-T. CHANG, J. J. COOK, J. J. LYNCH, M. A. HOLAHAN, G. R. SITKO, M. T. STRANIERI

Journal:

Year:

1997

File:

PDF, 29 KB

1997

5

ChemInform Abstract: Nonpeptide Glycoprotein IIb/IIIa Inhibitors: Substituted Quinazolinediones and Quinazolinones as Potent Fibrinogen Receptor Antagonists.

N. J. LIVERTON, D. J. ARMSTRONG, D. A. CLAREMON, D. C. REMY, J. J. BALDWIN, R. J. LYNCH, G. ZHANG, R. J. GOULD

Journal:

Year:

1998

File:

PDF, 38 KB

1998

6

ChemInform Abstract: Pyridazine Based Inhibitors of p38 MAPK.

Charles J. McIntyre, Gerald S. Ponticello, Nigel J. Liverton, Stephen J. O'Keefe, Edward A. O'Neill, Margaret Pang, Cheryl D. Schwartz, David A. Claremon

Journal:

Year:

2002

File:

PDF, 35 KB

2002

7

Cyclic benzamidines as orally efficacious NR2B-selective NMDA receptor antagonists

Kevin T. Nguyen, Christopher F. Claiborne, John A. McCauley, Brian E. Libby, David A. Claremon, Rodney A. Bednar, Scott D. Mosser, Stanley L. Gaul, Thomas M. Connolly, Cindra L. Condra, Bohumil Bednar

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 145 KB

english, 2007

8

Non-peptide glycoprotein IIb/IIIa inhibitors. 6. Design and synthesis of rigid, centrally constrained non-peptide fibrinogen receptor antagonists

B.C. Askew, C.J. McIntyre, C.A. Hunt, D.A. Claremon, R.J. Gould, R.J. Lynch, D.J. Armstrong

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 295 KB

english, 1995

9

Synthesis and evaluation of novel tricyclic benzo[4.5]cyclohepta[1.2]pyridine derivatives as NMDA/NR2B antagonists

Charles J. McIntyre, John A. McCauley, Bohumil Bednar, Rodney A. Bednar, John W. Butcher, David A. Claremon, Michael E. Cunningham, Roger M. Freidinger, Stanley L. Gaul, Carl F. Homnick, Ken S. Koblan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 579 KB

english, 2009

10

An efficient chemoselective synthesis of nitriles from primary amides

David A. Claremon, Brian T. Phillips

Journal:

Tetrahedron Letters

Year:

1988

Language:

english

File:

PDF, 171 KB

english, 1988

11

Hantzsch 1,2,3,4-tetrahydropyridines related to calcium antagonists. Two synthetic approaches.

David A. Claremon, Steven D. Young

Journal:

Tetrahedron Letters

Year:

1985

Language:

english

File:

PDF, 236 KB

english, 1985

12

A mild method for the synthesis of 2-ketopyrroles from carboxylic acids

K.C. Nicolaou, D.A. Claremon, D.P. Papahatjis

Journal:

Tetrahedron Letters

Year:

1981

Language:

english

File:

PDF, 225 KB

english, 1981

13

Pyridazine based inhibitors of p38 MAPK

Charles J McIntyre, Gerald S Ponticello, Nigel J Liverton, Stephen J O’Keefe, Edward A O’Neill, Margaret Pang, Cheryl D Schwartz, David A Claremon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 143 KB

english, 2002

14

Orally Efficacious NR2B-Selective NMDA Receptor Antagonists

Christopher F Claiborne, John A McCauley, Brian E Libby, Neil R Curtis, Helen J Diggle, Janusz J Kulagowski, Stuart R Michelson, Kenneth D Anderson, David A Claremon, Roger M Freidinger, Rodney A Bedn

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 148 KB

english, 2003

15

Novel 5-cyclopropyl-1,4-benzodiazepin-2-ones as potent and selective IKs-blocking class III antiarrhythmic agents

John W Butcher, Nigel J Liverton, David A Claremon, Roger M Freidinger, Nancy K Jurkiewicz, Joseph J Lynch, Joseph J Salata, Jixin Wang, Christine M Dieckhaus, Donald E Slaughter, Kamlesh Vyas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 148 KB

english, 2003

16

Corrigendum to ‘Novel 5-Cyclopropyl-1,4-benzodiazepine-2-ones as Potent and Selective IKs-Blocking Class III Antiarrhythmic Agents’: [Bioorg. Med. Chem. Lett. 13 (2003) 1165]

John W Butcher, Nigel J Liverton, David A Claremon, Roger M Freidinger, Nancy K Jurkiewicz, Joseph J Lynch, Joseph J Salata, Jixin Wang, Christine M Dieckhaus, Donald E Slaughter, Kamlesh Vyas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 65 KB

english, 2003

17

Nonpeptide glycoprotein IIb/IIIa inhibitors. 13. design and synthesis of an orally active pyrazolopiperazinone nonpeptide fibrinogen receptor antagonist

B.C. Askew, C.J. McIntyre, C.A. Hunt, D.A. Claremon, J.J. Baldwin, P.S. Anderson, R.J. Gould, R.J. Lynch, C.C-T. Chang, J.J. Cook, J.J. Lynch, M.A. Holahan, G.R. Sitko, M.T. Stranieri

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 270 KB

english, 1997

18

Nonpeptide glycoprotein IIb/IIIa inhibitors: Substituted quinazolinediones and quinazolinones as potent fibrinogen receptor antagonists

Nigel J. Liverton, Donna J. Armstrong, David A. Claremon, David C. Remy, John J. Baldvin, Robert J. Lynch, Guixiang Zhang, Robert J. Gould

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 209 KB

english, 1998

19

N-phenylselenophthalimide (NPSP) : A valuable selenenylating agent

K.C. Nicolaou, N.A. Petasis, D.A. Claremon

Journal:

Year:

1985

Language:

english

File:

PDF, 722 KB

english, 1985

20

Synthesis of 4,5-dihydroazepine-3,6-dicarboxylate derivatives by stereoselective ring expansion-nucleophilic addition to 4-.alpha.-chloroalkyl-1,4-dihydropyridine-3,5-dicarboxylates

Claremon, David A., McClure, David E., Springer, James P., Baldwin, John J.

Journal:

Journal of Organic Chemistry

Year:

1984

Language:

english

File:

PDF, 475 KB

english, 1984

21

Structure-Based Design Technology Contour and Its Application to the Design of Renin Inhibitors

Ishchenko, Alexey, Liu, Zhijie, Lindblom, Peter, Wu, Guosheng, Jim, Kam-Chuen, Gregg, Richard D., Claremon, David A., Singh, Suresh B.

Journal:

Journal of Chemical Information and Modeling

Year:

2012

Language:

english

File:

PDF, 3.86 MB

english, 2012

22

ChemInform Abstract: Preparation of 3-Amino-1,4-benzodiazepin-2-ones via Direct Azidation with Trisyl Azide.

J. W. BUTCHER, N. J. LIVERTON, H. G. SELNICK, J. M. ELLIOT, G. R. SMITH, A. J. TEBBEN, D. A. PRIBUSH, J. S. WAI, D. A. CLAREMON

Journal:

Year:

1996

File:

PDF, 34 KB

1996

23

Diethyl 3,6-dihydro-2,4-dimethyl-2,6-methano-1,3-benzothiazocine-5,11-dicarboxylates as calcium entry antagonists: new conformationally restrained analogs of Hantzsch 1,4-dihydropyridines related to nitrendipine as probes for receptor-site conformation

Baldwin, John J., Claremon, David A., Lumma, Patricia K., McClure, David E., Rosenthal, Seth A., Winquist, Raymond J., Faison, Elizabeth P., Kaczorowski, Gregory J., Trumble, Mayme J., Smith, Graham M

Journal:

Journal of Medicinal Chemistry

Year:

1987

Language:

english

File:

PDF, 721 KB

english, 1987

24

Total synthesis of ionophore antibiotic X-14547A

Nicolaou, K. C., Papahatjis, D. P., Claremon, D. A., Magolda, R. L., Dolle, R. E.

Journal:

Journal of Organic Chemistry

Year:

1985

Language:

english

File:

PDF, 2.54 MB

english, 1985

25

4-Oxospiro[benzopyran-2,4'-piperidines] as class III antiarrhythmic agents. Pharmacological studies on 3,4-dihydro-1'-[2-(benzofurazan-5-yl)ethyl]-6-methanesulfonamidospiro[(2H)-1-benzopyran-2,4'-piperidin]-4-one (L-691,121)

Elliott, Jason M., Selnick, Harold G., Claremon, David A., Baldwin, John J., Buhrow, Susan A., Butcher, John W., Habecker, Charles N., King, Stella W., Lynch, Joseph J.

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 443 KB

english, 1992

26

Carbocyclic thromboxane A2: Aggrevation of myocardial ischemia by a new synthetic thromboxane A2 analog

Edward F. Smith III, Allan M. Lefer, David Aharony, J.Bryan Smith, Ronald L. Magolda, David Claremon, Kyriacos C. Nicolaou

Journal:

Year:

1981

Language:

english

File:

PDF, 755 KB

english, 1981

27

Carbocyclic thromboxane A2

Nicolaou, K. C., Magolda, R. L., Claremon, D. A.

Journal:

Journal of the American Chemical Society

Year:

1980

Language:

english

File:

PDF, 890 KB

english, 1980

28

Organolithium addition to aldehyde dimethylhydrazones: a highly diastereocontrolled synthesis of threo 2-amino alcohols, and (1R,2R)-(-)-norpseudoephedrine

Claremon, David A., Lumma, Patricia K., Phillips, Brian T.

Journal:

Journal of the American Chemical Society

Year:

1986

Language:

english

File:

PDF, 285 KB

english, 1986

29

NR2B-Selective N -Methyl- d -aspartate Antagonists: Synthesis and Evaluation of 5-Substituted Benzimidazoles

McCauley, John A., Theberge, Cory R., Romano, Joseph J., Billings, Susan B., Anderson, Kenneth D., Claremon, David A., Freidinger, Roger M., Bednar, Rodney A., Mosser, Scott D., Gaul, Stanley L., Conn

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 123 KB

english, 2004

30

Total synthesis of ionophore antibiotic X-14547A. 1. Enantioselective synthesis of the tetrahydropyran and tetrahydroindan building blocks

Nicolaou, K. C., Papahatjis, D. P., Claremon, D. A., Dolle, R. E.

Journal:

Journal of the American Chemical Society

Year:

1981

Language:

english

File:

PDF, 346 KB

english, 1981

31

Total synthesis of ionophore antibiotic X-14547A. 2. Coupling of the tetrahydropyran and tetrahydroindan systems and construction of the butadienyl and ketopyrrole moieties

Nicolaou, K. C., Claremon, D. A., Papahatjis, D. P., Magolda, R. L.

Journal:

Journal of the American Chemical Society

Year:

1981

Language:

english

File:

PDF, 408 KB

english, 1981

32

154 A novel factor XIIIa inhibitor enhances clot lysis rates

Freund, K.F., Gaul, S.L., Doshi, K.P., Claremon, D.A., Remy, D.C., Baldwin, J.J., Friedman, P.A., Stern, A.M.

Journal:

Fibrinolysis and Proteolysis

Year:

1988

Language:

english

File:

PDF, 141 KB

english, 1988

33

N-Phenylselenophthalimide. A useful reagent for the facile transformation of (1) carboxylic acids into either selenol esters or amides and (2) alcohols into alkyl phenyl selenides

Grieco, Paul A., Jaw, John Yan, Claremon, D. A., Nicolaou, K. C.

Journal:

Journal of Organic Chemistry

Year:

1981

Language:

english

File:

PDF, 380 KB

english, 1981

34

An electronic environment and contact direction sensitive scoring function for predicting affinities of protein–ligand complexes in Contour®

Lindblom, Peter R., Wu, Guosheng, Liu, Zhijie, Jim, Kam-Chuen, Baldwin, John J., Gregg, Richard E., Claremon, David A., Singh, Suresh B.

Journal:

Journal of Molecular Graphics and Modelling

Year:

2014

Language:

english

File:

PDF, 1.38 MB

english, 2014

35

Non-Peptide Glycoprotein IIb/IIIa Inhibitors. 17. Design and Synthesis of Orally Active, Long-Acting Non-Peptide Fibrinogen Receptor Antagonists

Askew, Benny C., Bednar, Rodney A., Bednar, Bohumil, Claremon, David A., Cook, Jacquelynn J., McIntyre, Charles J., Hunt, Cecila A., Gould, Robert J., Lynch, Robert J., Lynch,, Joseph J., Gaul, Stanle

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 289 KB

english, 1997

36

Total synthesis of (.+-.)-zoapatanol

Nicolaou, K. C., Claremon, D. A., Barnette, W. E.

Journal:

Journal of the American Chemical Society

Year:

1980

Language:

english

File:

PDF, 277 KB

english, 1980

37

Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current I Ks by ( R )-2-(2,4- Trifluoromethyl)- N -[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1 H -benzo[ e ][1,4]diazepin-3-yl]acetamide

Selnick, Harold G., Liverton, Nigel J., Baldwin, John J., Butcher, John W., Claremon, David A., Elliott, Jason M., Freidinger, Roger M., King, Stella A., Libby, Brian E., McIntyre, Charles J., Pribush

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 100 KB

english, 1997

38

Transglutaminase Inhibition by 2-[(2-Oxopropyl)thio]imidazolium Derivatives: Mechanism of Factor XIIIa Inactivation

Freund, Kurt F., Doshi, Kundan P., Gaul, Stanley L., Claremon, David A., Remy, David C., Baldwin, John J., Pitzenberger, Steven M., Stern, Andrew M.

Journal:

Year:

1994

Language:

english

File:

PDF, 1.83 MB

english, 1994

39

Design and Synthesis of Potent, Selective, and Orally Bioavailable Tetrasubstituted Imidazole Inhibitors of p38 Mitogen-Activated Protein Kinase

Liverton, Nigel J., Butcher, John W., Claiborne, Christopher F., Claremon, David A., Libby, Brian E., Nguyen, Kevin T., Pitzenberger, Steven M., Selnick, Harold G., Smith, Garry R., Tebben, Andrew, Va

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 335 KB

english, 1999

40

N-Phenylselenophthalimide (N-PSP) and N-phenylselenosuccinimide (N-PSS). Two versatile carriers of the phenylseleno group. Oxyselenation of olefins and a selenium-based macrolide synthesis

Nicolaou, K. C., Claremon, D. A., Barnette, W. E., Seitz, S. P.

Journal:

Journal of the American Chemical Society

Year:

1979

Language:

english

File:

PDF, 399 KB

english, 1979

41

Reversal of the phenylseleno- and phenylsulpheno-cyclizations. Synthesis of olefins from phenylseleno- and phenylsulpheno-lactones, phenylselenoethers, and ?-hydroxyselenides

Nicolaou, Kyriacos C., Sipio, William J., Magolda, Ronald L., Claremon, David A.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1979

Language:

english

File:

PDF, 189 KB

english, 1979

42

Pharmacological characterization of the selective 11β-hydroxysteroid dehydrogenase 1 inhibitor, BI 135585, a clinical candidate for the treatment of type 2 diabetes

Hamilton, Bradford S., Himmelsbach, Frank, Nar, Herbert, Schuler-Metz, Annette, Krosky, Paula, Guo, Joan, Guo, Rong, Meng, Shi, Zhao, Yi, Lala, Deepak S., Zhuang, Linghang, Claremon, David A., McGeeha

Journal:

European Journal of Pharmacology

Year:

2015

Language:

english

File:

PDF, 949 KB

english, 2015

43

Antiarrhythmic Efficacy of Selective Blockade of the Cardiac Slowly Activating Delayed Rectifier Current, IKs, in Canine Models of Malignant Ischemic Ventricular Arrhythmia

Lynch, J. J., Houle, M. S., Stump, G. L., Wallace, A. A., Gilberto, D. B., Jahansouz, H., Smith, G. R., Tebben, A. J., Liverton, N. J., Selnick, H. G., Claremon, D. A., Billman, G. E.

Journal:

Year:

1999

Language:

english

File:

PDF, 409 KB

english, 1999

44

Preparation of 5-Substituted 2-Mercapto-1-methylimidazoles. Direct Metalation of 2-Mercapto-1-methylimidazole

Phillips, Brian T., Claremon, David A., Varga, Sandor L.

Journal:

Year:

1990

File:

PDF, 204 KB

1990

45

Preparation of 7-Alkyl-2,3,6,7-tetrahydro-4-alkyl-2-oxo- 1 H -1,3-diazepine-5-carboxylates by Ring Expansion-Nucleophilic Addition

Claremon, David A., Rosenthal, Seth A.

Journal:

Year:

1986

File:

PDF, 140 KB

1986

46

One-Pot Synthesis of Spiro Isochromane-3,3′-piperidines, -3,4′-piperidines and -3,3′-pyrrolidines

J. W. Butcher, D. A. Claremon

Year:

1993

File:

PDF, 173 KB

1993

47

Novel Rigid Calcium-Entry Blockers: Intramolecular Reactions of 1,4-Dihydropyridine Derivatives

D. A. Claremon, J. Hirshfield, P. K. Lumma, D. E. Mcclure, J. P. Springer

Year:

1986

File:

PDF, 378 KB

1986

48

In Vivo Canine Cardiac Electrophysiologic Profile of 1,4-Benzodiazepine Iks Blockers

Stump, Gary L., Smith, Garry R., Tebben, Andrew J., Jahansouz, Hossain, Salata, Joseph J., Selnick, Harold G., Claremon, David A., Lynch, Joseph J.

Journal:

Journal of Cardiovascular Pharmacology

Year:

2003

Language:

english

File:

PDF, 402 KB

english, 2003

49

VTP-27999: A NOVEL RENIN INHIBITOR WITH POTENTIAL FOR SUPERIOR NEPHROPROTECTION

Gregg, R., McGeehan, G., Bryson, C., Danser, A., Claremon, D., Balcarek, J.

Journal:

Journal of Hypertension

Year:

2011

Language:

english

File:

PDF, 70 KB

english, 2011

50

ChemInform Abstract: Organolithium Addition to Aldehyde Dimethylhydrazones: A Highly Diastereocontrolled Synthesis of Threo 2-Amino Alcohols and (1R,2R)-(-)-Norpseudoephedrine.

CLAREMON, D. A., LUMMA, P. K., PHILLIPS, B. T.

Journal:

Year:

1987

File:

PDF, 247 KB

1987

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